Open Access Highly Accessed Research

Selection for resistance to oseltamivir in seasonal and pandemic H1N1 influenza and widespread co-circulation of the lineages

Daniel A Janies*, Igor O Voronkin, Jonathon Studer, Jori Hardman, Boyan B Alexandrov, Travis W Treseder and Chandni Valson

Author Affiliations

Department of Biomedical Informatics, The Ohio State University, College of Medicine, Columbus, OH 43210 USA

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International Journal of Health Geographics 2010, 9:13  doi:10.1186/1476-072X-9-13

Published: 24 February 2010

Additional files

Additional file 1:

Character optimization of H275Y on a tree based on NA segments from the pandemic H1N1 lineage. This file is in scalable portable document format. The mutation H275Y visualized in color (green = H = susceptible to oseltamivir: red = Y = resistant to oseltamivir) on the best tree.

Format: PDF Size: 1.3MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

Accession numbers of the neuraminidase nucleotide sequences used in the phylogenetic and geographic study of pandemic H1N1 influenza A. GISAID sequences are available at http://www.gisaid.org webcite. GenBank sequences are available at http://ncbi.nlm.nih.gov webcite.

Format: DOC Size: 503KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 3:

Character optimization of H275Y on a tree based on NA segments from the seasonal H1N1 lineage. This file is in scalable portable document format. The mutation H275Y visualized in color (green = H = susceptible to oseltamivir: red = Y = resistant to oseltamivir) on the best tree.

Format: PDF Size: 821KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 4:

Accession numbers of the neuraminidase nucleotide sequences used in the phylogenetic and geographic study of seasonal H1N1 influenza A. GISAID sequences are available at http://www.gisaid.org webcite. GenBank sequences are available at http://ncbi.nlm.nih.gov webcite.

Format: DOC Size: 355KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 5:

Heuristic maximum likelihood tree based on NA segments from the pandemic H1N1 lineage. The file is in nexus format.

Format: NEX Size: 115KB Download file

Open Data

Additional file 6:

Heuristic maximum likelihood tree based on NA segments from the seasonal H1N1 lineage. The file is in nexus format.

Format: NEX Size: 76KB Download file

Open Data

Additional file 7:

An interactive visualization of populations of zanamivir-resistant seasonal H1N1. A KML file suitable for viewing with Google Earthâ„¢ http://earth.google.com webcite or other virtual globe software. Once the user opens the file in Google Earth, the user will see white points that represent isolates of seasonal H1N1 that are resistant to zanamivir.

Format: KMZ Size: KB Download file

Open Data

Additional file 8:

An interactive visualization of populations of oseltamivir-resistant seasonal H1N1 influenza and pandemic influenza in co-circulation across the globe. A KML file suitable for viewing with Google Earthâ„¢ http://earth.google.com webcite or other virtual globe software. Once the user opens the KML file in Google Earth, the user will see red points that represent isolates of seasonal H1N1 that are resistant to oseltamivir. Green points represent isolates of pandemic H1N1 that are susceptible to oseltamivir. Yellow points represent isolates of pandemic H1N1 that are resistant to oseltamivir. Clicking on a point will reveal if various isolates co-circulate in that region.

Format: KMZ Size: KB Download file

Open Data

Additional file 9:

Acknowledgements. Acknowledgements for researchers and institutions who submitted sequence data to GISAID and GenBank.

Format: DOC Size: 43KB Download file

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Open Data