Henry E Wang*, Randolph S Devereaux, Donald M Yealy, Monika M Safford and George Howard
Corresponding author: Henry E Wang firstname.lastname@example.org
International Journal of Health Geographics 2010, 9:9 doi:10.1186/1476-072X-9-9
William B. Grant
(2011-12-19 11:27) Sunlight, Nutrition and Health Research Center
The epidemiology of sepsis in the United States led to an ecological study finding
a role for solar UVB and vitamin D. Characteristics included in that study were racial
disparities, seasonality, comorbid diseases, and geographical location.
Grant WB. Solar ultraviolet-B irradiance and vitamin D may reduce the risk of septicemia
(the title should have used sepsis).
Vitamin D also reduces the risk of respiratory diseases such as influenza and pneumonia,
in part through induction of cathelicidin, in part through shifting cytokine production
away from pro-inflammatory ones.
The high rates of sepsis in the southeast corresponds to the region of highest deaths
from lung cancer. Respiratory infections comprise the majority of sepsis-attributed
deaths, suggesting that smoking and diet may contribute to risk of sepsis.
I receive or have received funding from the UV Foundation (McLean, VA), Bio-Tech-Pharmacal
(Fayetteville, AR), and the Vitamin D Council (San Luis Obispo, CA).
(2010-05-11 14:57) Emory University
The finding that sepsis mortality varies significantly across the U.S. is important
and likely explains part of the healthcare disparities observed with this condition.
A previous study using similar methodology reported similar findings regarding geographic
variation, but also included analysis of incident cases and linked geographic and
seasonal variations in sepsis incidence: see Danai P, et al. Critical Care Medicine
2007; 35: 410–415.
BioMed Central Ltd unless otherwise stated. Part of Springer Science+Business Media.